The B-PEN database
and the research

Participate in a research programme

The use of Logipren is coupled with the development of a centralised prescription database. This data is completely anonymised (for both patient and prescriber) within the institutions, before being sent to the data warehouse.

The main aim is to provide neonatology departments with the compared results of their prescription practices (B-PEN research programme conducted by the University Hospital of La Réunion). Moreover, the database allows the development of other research programmes.

A Scientific Committee has been established, consisting of doctors and pharmacists from all relevant hospital wards, representatives from learned societies (SFN, SFPC) and research units(CEPOI, INSERM.

Several research topics are currently being studied: prescription of antibiotics, antifungals and analgesics, the exposure of newborns to parabens via drugs, etc.
This research forms the subject of medical theses, science theses and publications in peer-reviewed journals.

Comparing prescription practices

The B-PEN database enables a regular comparison of prescription practices between care units.

A report is drafted each year containing the results from each unit and graphs comparing these results.

The comparison is anonymous: each care unit is given a number which is used for the results presented. Each unit knows their own number but not that of the other units.

The results are analysed by doctors and pharmacists from all the hospitals at an annual meeting. They guide the research implemented within the B-PEN database.

Ongoing research

  • Vaccination of premature infants : Marie-Laure Charkaluk (St-Vincent de Paul, Lille)
  • Mupirocin : Isabelle Ligi (APHM, University Hospital La Conception)
  • Acid suppressive medications : Manon Tauzin (CHI Créteil)
  • Opiate equianalgesia : Manon Tauzin (CHI Créteil)
  • Dexmedetomidine in ventilated extremely premature babies : Camille Irving (CHI Créteil)
  • Prescriptions for children >1 year in pediatric intensive care : Béatrice Gouyon (Logipren)
  • Epoetin Beta : Roselyne Brat (CHR Orléans)

Do not hesitate to contact us to participate or suggest research topics

Scientific articles

Postnatal corticosteroid exposure in very preterm infants : A french cohort study  

Frontiers in Pharmacology, 2023

Iacobelli, S., Allamèle-Moutama, K., Lorrain, S., Gouyon, B., Gouyon, J. B., Bonsante, F., & Logipren Collaborative Working Group (2023).

Postnatal corticosteroid exposure in very preterm infants: A French cohort study. Frontiers in pharmacology14, 1170842.

https://pubmed.ncbi.nlm.nih.gov/37089932/

https://doi.org/10.3389/fphar.2023.1170842

Paraben exposure through drugs in the neonatal intensive care unit : a regional chohort study

Frontiers in Pharmacology, 2023

Iacobelli, S., Commins, M., Lorrain, S., Gouyon, B., Ramful, D., Richard, M., Grondin, A., Gouyon, J. B., & Bonsante, F. (2023).

Paraben exposure through drugs in the neonatal intensive care unit: a regional cohort study. Frontiers in pharmacology, 14, 1200521.

https://pubmed.ncbi.nlm.nih.gov/37361223/

https://doi.org/10.3389/fphar.2023.1200521

Frequencies, Modalities, Doses and Duration of Computerized Prescriptions for Sedative, Analgesic, Anesthetic and Paralytic Drugs in Neonates Requiring Intensive Care: A Prospective Pharmacoepidemiologic Cohort Study in 30 French NICUs From 2014 to 2020

Frontiers in Pharmacology, 2022

Tauzin, M., Gouyon, B., Hirt, D., Carbajal, R., Gouyon, J. B., Brunet, A. C., Ortala, M., Goro, S., Jung, C., & Durrmeyer, X. (2022).

Frequencies, Modalities, Doses and Duration of Computerized Prescriptions for Sedative, Analgesic, Anesthetic and Paralytic Drugs in Neonates Requiring Intensive Care : A Prospective Pharmacoepidemiologic Cohort Study in 30 French NICUs From 2014 to 2020. Frontiers in pharmacology13, 939869. 

Copy the URL to download : https://www.logipren.com/wp-content/uploads/2022/07/2022.07.18_Article-antalgiques-M-Tauzin.pdf

https://doi.org/10.3389/fphar.2022.939869

Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units

Antibiotics, 2021

Martin-Mons, S., Gouyon, B., Lorrain, S., Abasse, S., Alexandre, C., Binson, G., Brat, R., Caeymaex, L., Couringa, Y., Desbruyeres, C., Meglio, M. D., Escourrou, G., Flamein, F., Flechelles, O., Girard, O., Kermorvant-Duchemin, E., Lapillonne, A., Lafon, C., Di Maio, M., Mazeiras, G., … Gouyon, J. B. (2021).

Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units. Antibiotics (Basel, Switzerland)10(11), 1422. 

Copy the URL to download :  https://www.logipren.com/wp-content/uploads/2022/07/2021.11.21_Prescription-of-Aminoglycosides-in-23-French-Neonatal-Intensive-Care-units.pdf

https://doi.org/10.3390/antibiotics10111422

Antibiotics prescription over three years in a French benchmarking network of 23 Level 3 Neonatal Wards

Frontiers in Pharmacology, 2020

Martin-Mons, S., Lorrain, S., Iacobelli, S., Gouyon, B., Gouyon, J. B., & B-PEN Study Group (2021).

Antibiotics Prescription Over Three Years in a French Benchmarking Network of 23 Level 3 Neonatal Wards. Frontiers in pharmacology11, 585018. 

https://www.frontiersin.org/articles/10.3389/fphar.2020.585018/abstract

https://doi.org/10.3389/fphar.2020.585018

Drug exposure for PDA closure in France: a prospective, cohort-based, analysis

European journal of clinical pharmacology.2020

Iacobelli, S., Lorrain, S., Gouyon, B., Gambacorta, S., Laforgia, N., Gouyon, J. B., & Bonsante, F. (2020).

Drug exposure for PDA closure in France: a prospective, cohort-based, analysis. European journal of clinical pharmacology76(12), 1765–1772. 

https://pubmed.ncbi.nlm.nih.gov/32740771/

https://doi.org/10.1007/s00228-020-02974-1

Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research

Public Library of Science one (Plos One),2019

Gouyon, B., Martin-Mons, S., Iacobelli, S., Razafimahefa, H., Kermorvant-Duchemin, E., Brat, R., Caeymaex, L., Couringa, Y., Alexandre, C., Lafon, C., Ramful, D., Bonsante, F., Binson, G., Flamein, F., Moussy-Durandy, A., Di Maio, M., Mazeiras, G., Girard, O., Desbruyeres, C., Mourdie, J., … Gouyon, J. B. (2019).

Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research. PloS one14(9), e0222667. 

https://pubmed.ncbi.nlm.nih.gov/31536560/

https://doi.org/10.1371/journal.pone.0222667

A Computer Prescribing Order Entry-Clinical Decision Support system designed for neonatal care: results of the 'preselected prescription' concept at the bedside

Journal of clinical pharmacy and therapeutics,2017

Gouyon, B., Iacobelli, S., Saliba, E., Quantin, C., Pignolet, A., Jacqz-Aigrain, E., & Gouyon, J. B. (2017).

A Computer Prescribing Order Entry-Clinical Decision Support system designed for neonatal care: results of the 'preselected prescription' concept at the bedside. Journal of clinical pharmacy and therapeutics42(1), 64–68. 

https://pubmed.ncbi.nlm.nih.gov/27882560/

https://doi.org/10.1111/jcpt.12474